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Tamsulosin selectively and competitively blocks postsynaptic alpha-1 adrenergic receptors located in the smooth muscle of the prostate, bladder neck and prostatic urethra , and alpha-1-adrenergic receptors, mainly located in the body of the bladder define equipoise. This leads to a reduction in smooth muscle tone of the prostate, bladder neck and prostatic urethra and detrusor improve function. This reduces the symptoms of obstruction and irritation associated with benign prostatic hyperplasia. Typically, the therapeutic effect is at 2 weeks after the beginning of reception of the preparation, although some patients, a decrease in symptoms observed after the first dose. Tamsulosin ability to influence the alpha-1A adrenoceptors 20 times greater than its ability to interact with alpha-1 adrenoceptors located in vascular smooth muscle. Due to such a high selectivity of the drug does not cause any clinically significant reduction in systemic blood pressure  in both hypertensive patients and in patients with normal baseline .

Pharmacodynamics finasteride

Finasteride – a synthetic 4-azasteroid, a specific inhibitor of the intracellular enzyme 5-alpha-reductase type II. Last converts testosterone into the more active androgen – 5-alpha-dihydrotestosterone .The normal function and growth of the prostate gland, including its hypertrophied tissue is dependent on the conversion of testosterone to define equipoise. Finasteride has no effect on the androgenic receptors. In healthy volunteers, proliferation and apoptosis of prostate cells are balanced due to the interaction of factors that inhibit and stimulate growth. Although the etiological factors, on a molecular level causing prostatic hyperplasia are not yet known, probable that in this process  plays a role. Specific inhibitors of type II 5-alpha-reductase reduce the concentration  in the prostate and promote regression of prostate hyperplasia. According to clinical studies, treatment with finasteride rapidly reduces the concentration  in the plasma by 70%, resulting in a decrease in prostate volume. At constant reception statistically significant effects recorded after 3 months (decrease prostate volume by about 20%) and 7 months (decrease in severity of symptoms associated with benign prostatic hyperplasia).

In humans, there are two kinds of 5-alpha reductase inhibitor: I and P. Their distribution in tissues differently: in prostate, testis and epididymis, glans penis, scrotum, seminal vesicle, liver, and the chest occurs type II isozyme; Type I is found mainly in the skin of the head, back and chest, sebaceous glands, in the liver, kidney and adrenal glands. Finasteride inhibits primarily type II isozyme, is responsible for most of the  in the blood. A single dose of finasteride quickly and significantly change the concentration of define equipoise in plasma. A single dose of 5 mg of finasteride reducing DHT concentration in plasma is 75%, which is 24 o’clock reaches its minimum, and then returns to its original level within 7 days.

Repeated reception finasteride is effective. Finasteride decreases the concentration  in the prostate itself to <15% and provides a corresponding increase in testosterone in the prostate. Compared with surgical or chemical castration, treatment with finasteride is accompanied by a significantly greater decrease in the level  in the prostate. Prostate-specific antigen  – a sensitive and specific marker of prostate carcinoma androgenozavisimy. In most cases, after a few months of treatment with finasteride, a rapid decrease in  levels, and then setting it to low values. After 1 year receiving finasteride 5 mg average concentration  is reduced by 50%.

Finasteride does not exhibit affinity for androgen receptors and has no other hormonal action. Following the discovery of the 5-alpha-reductase deficiency syndrome and the description of the 5-alpha-reductase type II (male hermaphroditism type) the role of androgens in benign prostatic hyperplasia was again revised.

Prostate development is dependent ondefine equipoise strong androgen. When failure of 5-alpha-reductase in the background of normal or high testosterone levels in adulthood there is atrophy of the prostate.  Activates the androgen receptor to form after the accession to the dimers, which are entering into a relationship with  directly or indirectly, contribute to cell proliferation by changing the expression of genes responsible for proliferation and apoptosis. In the intact prostate apoptosis and proliferation processes are in equilibrium. Despite the fact that the factors that trigger prostate hyperplasia at the molecular level, are not known, the role of the  is very likely. Specific inhibitors of 5-alpha-reductase type II can reduce the concentration define equipoisein the prostate and promote regression of hyperplastic prostate.

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Absorption – high, time of onset of the maximum concentration  in plasma – 1-4 hours after ingestion. About 90% of the drug binds to plasma proteins. It is metabolized in the liver with the formation of active metabolites (mesoridazine and sulforidazin).  Equipoise cycle – pharmacologically more active than the starting material, has a greater  less bound to proteins, free concentration higher than that of thioridazine. Excretion in unchanged form and as metabolites – the kidneys (35%) in the bile. Provided with breast milk.

Indications
Schizophrenia, manic-depressive psychosis; neuroses, accompanied by fear, anxiety, agitation, tension, depressed mood, sleep disturbances, intrusive state; psychotic disorders, accompanied by hyperactivity and excitement; severe behavioral disorders associated with psychotic disorders or neurological diseases involving aggression, inability to long-term focus; abstinence syndrome (drug addiction, alcoholism); agitation of various origins; moderate and severe depression in adults; Huntington’s disease, tics; skin conditions with a strong and painful itching; in child psychiatry is used for behavioral disorders with increased psychomotor activity.

Contraindications:
Hypersensitivity, acute depression, comatose states from any cause, traumatic brain injuries, progressive system of the brain and spinal cord diseases; severe heart failure, severe hypotension, pheochromocytoma, porphyria, blood disorders (hypo-and aplastic processes). Pregnancy, lactation, children’s age (up to 4 years).

Precautions
When alcoholism equipoise cycle (predisposition to hepatotoxicity), pathological changes in the blood (impaired hematopoiesis), breast cancer (as a result of induced phenothiazine prolactin increases the potential risk of disease progression and resistance to the treatment of endocrine and cytotoxic drugs), angle-closure glaucoma, prostatic hyperplasia with clinical manifestations, liver and / or renal failure, gastric ulcer and duodenal ulcer (in the period of exacerbation); diseases accompanied by an increased risk of thromboembolic complications; Parkinson’s disease (amplified extrapyramidal effects); epilepsy; myxedema;chronic diseases accompanied by respiratory disorders (especially in children); Reye syndrome (increased risk of hepatotoxicity in children and adolescents); cachexia, vomiting (antiemetic effect of phenothiazines may mask vomiting associated with overdoses of other drugs). Elderly age.

Dosing and Administration
Inside. An individual dosage regimen. Adult equipoise cycle Acute psychosis, mania, schizophrenia and depression azhitatsionnyh: an outpatient basis – 150-400 mg per day; hospital – 250-800 mg per day. Treatment is usually started with a low dosage of 25-75 mg per day, gradually increasing to an optimal therapeutic dose, which is usually achieved within 7 days, and the antipsychotic effect is observed after 10-14 days.The course of treatment is several weeks. Maintenance daily dose: 75-200 mg once daily at bedtime. In the treatment of the elderly are usually used low doses: 30-100 mg per day. The drug should be withdrawn gradually. In light of mental and emotional disorders – 30-75 mg per day, with moderate disorders – 50-200 mg per day. To begin treatment with low doses of gradually increasing doses until the optimal therapeutic. In psychosomatic disorders: 10-75 mg per day. To suppress the strong itch, dose set individually, and it should not exceed 200 mg. Children 4 to 7 years – 10-20 mg sutki.Kratnost reception – 2-3 times a day. From 8 to 14 years – 20 30 mg per day. Multiplicity of reception – 3 times a day. From 15 to 18 years – 30-50 mg per day. Multiplicity of reception – 3 times a day. buy anabolic steroids online bruce lee’s workout anabolic steroids online uk

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Communication to plasma proteins is approximately 45%.Metabolism After reappointments accumulation of zopiclone and its metabolites occurs. Interindividual differences are insignificant. The main metabolites are the N-oxide derivative (pharmacologically active) and N-desmetilovy metabolite (pharmacologically inactive). The half-life of approximately 4.5 and 7.4 hours, respectively. At the recommended doses, the half-life of unchanged zopiclone is approximately 5 hours. The urine zopiclone displays (approximately 80%), mainly as metabolites, with stool output of approximately 16%. Specific groups of patients in elderly patients, despite the slight decrease in hepatic metabolism and lengthening half-life of approximately 7 hours equipoise only cycle drug accumulation plasma was not detected even with multiple assignment. in patients with renal insufficiency cumulation zopiclone or its metabolites were detected even after prolonged use. in patients with liver cirrhosis the clearance of zopiclone is reduced by approximately 40% in accordance with the decrease dimethylation process.

 

Indications
Treatment of transient, situational or chronic insomnia in adults (including difficulty falling asleep, nighttime awakenings and early).

Contraindications

 

  • hypersensitivity to zopiclone or any other components of the drug;
  • myasthenia gravis;
  • severe respiratory failure;
  • severe hepatic impairment;
  • syndrome “sleepy” apnea;
  • Pregnancy and breast-feeding;
  • age 18 years.Pregnancy and lactation
    is not recommended to use the drug during pregnancy and prescribe nursing mothers.

    Dosage and administration
    Treatment should be as short as possible and not exceed four weeks.
    Lengthening the duration of treatment in excess of the maximum allowable carried out after re-evaluation of the patient’s condition. The drug is taken before bedtime. The duration of treatment Transient insomnia: 2 to 5 days. Situational insomnia: 2 to 3 weeks. Chronic equipoise only cycle insomnia: duration of course of treatment is determined after consultation with a specialist. The recommended dose for adults – 7.5 mg. This dose must not be exceeded. Treatment of elderly patients and patients with impaired liver function, or chronic obstructive pulmonary disease begin with a dose of 3.75 mg and, if appropriate, increased to 7.5 mg. Although in cases of renal insufficiency cumulation zopiclone or its metabolites were not found in these patients recommend starting treatment with a dose of 3.75 mg.

     

    Side effects:
    The most common side effect observed in the appointment of zopiclone – a bitter taste in the mouth may also be:

  • dizziness, headache, residual drowsiness after waking;
  • Digestive Disorders: dyspepsia, nausea, dry mouth;
  • Allergic skin reactions such as itching and rashes, are extremely rare angioedema and anaphylactic reactions. Can occur anterograde amnesia. Psychiatric and paradoxical reactions Rare: nightmares, irritability, confusion, hallucinations, aggressiveness, confusion, depressed mood, incoordination, depression, inappropriate behavior with the possible development of amnesia. “Cancellation” syndrome and rebound insomnia observed after cessation of treatment. There have been isolated cases marked a slight increase in serum transaminases blood and / or alkaline phosphatase.Overdosing
    Overdosing it is usually manifested in the form of varying degrees of symptoms of central nervous system depression of somnolence to coma, depending upon the amount of drug received. First aid is gastric lavage, activated charcoal. If necessary, it is recommended symptomatic and supportive therapy in a hospital. Particular attention should be paid to equipoise only cycle respiratory and cardiovascular functions.
    Haemodialysis has little significance because of the large volume of distribution of zopiclone.
    Flumazenil can be used as an antidote.

    Drug interaction
    Not recommended concomitant use of alcohol as a sedative effect of zopiclone may be enhanced.
    Increased depressant effect on the central nervous system can occur in cases of co-administration with the antipsychotics, hypnotics, tranquilizers, sedatives, antidepressants, narcotic analgesics, antiepileptic drugs, anesthetics , antigistaminnmi drugs with a sedative effect, and erythromycin. The drug reduces the concentration of trimipramine in plasma and its effect.

    Cautions
    In appointing zopiclone must be remembered that although the risk and minimal, but can not completely eliminate the development of addiction to the drug and its abuse.
    The risk of dependence or abuse arises in the following cases:

  • violations of the dose and duration of treatment;
  • abuse of alcohol and / or drugs;
  • Use of alcohol or other psychotropic drugs. rebound insomnia syndrome “cancel” The risk of such phenomena after abrupt discontinuation of zopiclone can not be ruled out, especially after long-term treatment. Therefore recommended to gradually equipoise only cycle reduce the dose and notify the patient. Amnesia may occur anterograde amnesia, especially when sleep is interrupted or after a significant period of time between taking the drug and going to sleep.

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definition of equipoise

The drug is administered only intramuscularly (w / m) in institutions and in strict accordance with these instructions. Treatment starts with a test administration (in case of ineffectiveness of further therapy is impractical) and evaluate the response (the dynamics of growth hormone secretion of growth, symptoms associated with carcinoid tumor). The dosage regimen and duration of therapy is determined individually for each patient. Begin to 30 mg / m 1 every 14 days. In inefficiency can increase the frequency of administration of 1 injection every 10 days. Treatment of digestive organs fistula treatment begins with a test to definition of equipoise evaluate intramuscular injection response. In the case of reducing the volume of discharge from the fistula by more than 50% within 72 hours after injection, the drug is used one time in ten days until healing of fistulas. The maximum number of additional injections – 3. In 50% of patients complete closure of fistulas has been observed for 14 days.

Instructions for the preparation and administration of the drug mixing the freeze-dried with the supplied diluent should be performed immediately before injection buy equipoise by shaking the vial smooth movements, rotating the vial 20 or 30 times between the fingers until a homogeneous suspension of white or white with Valium a color shade. The suspension should not be mixed with other drugs.

Side effects: Local: itching, burning, mild transient pain at the injection site, sometimes accompanied by erythema. On the part of the digestive system organs: diarrhea or soft stools, steatorrhea, abdominal pain, flatulence, nausea, vomiting. With long-term use of the drug, the formation of gallstones (cholelithiasis asymptomatic). On the part of metabolism: rarely have seen an increase in glucose concentration, changes in glucose tolerance.

Overdose Symptoms: The side effects definition of equipoise from the gastrointestinal tract, electrolyte disturbances. Treatment: symptomatic.

Interaction with other drugs When concomitant administration of insulin amplifies its hypoglycemic effect, in this connection, the insulin dose should be adjusted. When concomitant administration with cyclosporine (orally), it is necessary to spend correction of doses of cyclosporine.

Cautions In appointing Somatulina patients with diabetes (both type 1 and type 2) should be regular monitoring of blood glucose and, if necessary, carry out correction doses of hypoglycemic drugs. When carcinoid tumors of the gastrointestinal treatment Somatulinom tract appointed after the removal of the existing intestinal obstruction by the tumor. In the treatment of acromegaly is necessary to closely monitor the state of the pituitary gland. prolonged treatment every 6 months is necessary to make an ultrasound examination of the gallbladder. If abnormal liver or renal function define equipoise is necessary to adjust the dose of the drug. It is necessary to warn patients undergoing definition of equipoise treatment Somatulinom a possible violation of the reproductive function, as well as the appropriateness of the use of contraceptives during treatment Somatulinom and for 3 months after treatment.

Product form 30 mg lanreotide in a bottle of slightly darkened hydrolytic glass , rubber stoppers of chlorobutyl beneath an aluminum run with a hole for the needle in the center and covered with a protective plastic cover the control of the first opening. In 2 ml of solvent in an ampoule colorless glass of hydrolytic . One empty sterile disposable polypropylene syringe with a capacity of 3 ml and two sterile disposable needle tips (needle size 1,20 x 40 mm) in a blister pack made of PVC and laminated paper. One vial lanreotide, one vial with a solvent, a blister pack with two syringe needles and placed in a cardboard box, together definition of equipoise with instructions for use.

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equipoise vs deca

Because  therapy complications depend on the dose and duration of treatment, the need to make a decision on such treatment in each case based on the analysis of risk / benefit ratio, and determine the treatment duration and frequency of administration.
The effectiveness of equipoise vs deca has not been confirmed in septic shock. There was an increased mortality in patients at high risk (eg, an increase in serum creatinine of more than 2.0 mg / dL, or secondary infections).
Patients who may be exposed to stress on the background of  therapy showed an increase in the dose before, during and after the stressful situation.
Due to the fact that the observed increase in mortality at 2 weeks after head injury in patients treated with methylprednisolone sodium succinate, compared with placebo, equipoise vs deca should not be used in brain edema, head trauma conditioned. Causation deaths with methylprednisolone sodium succinate is not installed.

  • The therapy  some infections can occur in the form of worn, moreover, may develop a new infection. In the application of corticosteroids may be reduced resistance to infection, and also reduced the body’s ability to localize the infection process. The development of infections caused by various pathogens, such as viruses, bacteria, fungi, protozoa and helminths, which are located in various human organ systems, may be associated with the use of corticosteroids, both as monotherapy and in combination with other immunosuppressive agents acting on cellular immunity, humoral immunity, or neutrophil function. These infections can occur not hard, however, in some cases, possibly severe course, and even death. And than higher doses of corticosteroids are used, the higher the probability of infectious complications.
  • Patients receiving treatment with corticosteroids at the doses that have an immunosuppressive effect, is contraindicated the introduction of live or live attenuated vaccines, but it is possible to introduce killed or inactivated vaccines, but the reaction to the introduction of such vaccines may be reduced. Patients receiving treatment with corticosteroids at doses that do not produce an immunosuppressive action, immunization can be carried out by the appropriate indications.
  • Use of the drug Solu-Medrol ® with active tuberculosis should be restricted to cases of fulminant and disseminated tuberculosis when corticosteroids are used to treat the disease in conjunction with appropriate antituberculous chemotherapy.
  • If the drug is prescribed to patients with latent tuberculosis equipoise vs deca or positive tuberculin skin test, treatment should be under strict medical supervision, because the possible reactivation of the disease. During prolonged therapy with these patients should receive appropriate prophylactic treatment.
  • Since patients receiving parenteral therapy with corticosteroids, in rare cases may develop anaphylactoid reactions (eg, bronchospasm), should take appropriate preventive measures, especially if this patient have a history of allergic reactions to any drugs prior to administration of the drug.

 

 

issuance

  • Lyophilizate equipoise vs deca for preparation of solution for intravenous and intramuscular administration of 250 mg: Primary package: 250 mg of the active substance, and 4 ml of solvent in dvuhemkostnye vials colorless class I glass, sealed with two stoppers butyl rubber (one separates the two containers, the other closes the bottle top) activator with plastic cork over the top; Secondary packaging: one bottle with instruction for use in a carton box.
  • Lyophilizate for preparation of solution for injection 500 mg or 1000 mg: LYOPHILIZATE: 500 mg or 1000 mg of the active substance in vials of class I colorless glass, sealed with butyl rubber stoppers, aluminum caps obkatat with plastic protective covers; Solvent: 7.8 ml (to 500 mg) or 15.6 ml (for 1000 mg) in bottles from colorless glass class I, sealed with butyl rubber stoppers, run-aluminum caps with plastic protective covers, Secondary packing: one vial of lyophilisate and one vial with solvent (1 set), together with instructions for use in a carton box.

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