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clinical equipoise


Drowsiness, confusion, urinary retention, disorientation, coma, areflexia, hyperreflexia, dry mouth, nasal congestion, postural hypotension, respiratory center clinical equipoise depression, convulsions, hypothermia. Treatment is symptomatic, aimed at reducing the suction and the acceleration of excretion of the drug. Gastric lavage solution of activated charcoal, laxatives (eg magnesium sulfate). Introduction isotonic solutions.Control function of the cardiovascular and respiratory systems. If you want to consistently perform artificial respiration and monitoring functions of the cardiovascular system, prevent the development of metabolic acidosis. There is no specific antidote.

Interaction with other drugs
The synergy of action with general anesthetics, opioids, barbiturates, ethanol, atropine. It enhances the hepatotoxic effects of antidiabetic drugs. With amphetamine –  clinical equipoise acts antagonistically. Since levodopa – reduced antiparkinsonian action. The use of adrenaline – can lead to a sudden and pronounced reduction in blood pressure. With guanetidinom reduces the antihypertensive effect of the latter, but enhances the effect of other antihypertensive drugs, which increases the risk of a significant orthostatic hypotension. It reduces the effect of anticoagulants. Action sonapaks can weaken anticonvulsants, cimetidine.Quinidine – cardiodepressive potentiates the action. Ephedrine – contributes to a paradoxical decrease in blood pressure. Sympathomimetics – reinforce arrhythmogenic effect. Probucol, astemizole, cisapride, disopyramide, erythromycin, pimozide, quinidine, procainamide, and contribute to further prolongation of the  interval, which increases the risk of ventricular tachycardia. Antithyroid drugs increase the risk of agranulocytosis. Reduces means reducing appetite (except for fenfluramine). Reduces the effectiveness of the action of the emetic apomorphine enhances its inhibitory effect on the central nervous system. Increases concentration of plasma prolactin and bromocriptine prevents action.

In a joint application with tricyclic antidepressants, maprotiline, clinical equipoise inhibitors, antihistamines may lengthening and strengthening of sedative and anticholinergic effects. With thiazide diuretics – strengthening of hyponatremia. With lithium medications – reducing the absorption in the gastrointestinal tract, increasing the rate of excretion of the lithium ions by the kidneys, increased severity of extrapyramidal disorders, early signs of lithium toxicity (nausea and vomiting) may be masked antiemetic effect of perphenazine. In combination with beta-blockers enhances the hypotensive effect, it increases the risk of irreversible retinopathy, arrhythmias, and tardive dyskinesia.

In the period of treatment is necessary to monitor the morphological composition of the blood; refrain from the use of ethanol and activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Effects on ability to road management and maintenance clinical equipoise machinery in motion.
Sonapaks weakens motor coordination, and reduces the reaction, especially at the beginning of the treatment, so the period of drug treatment should refrain from driving vehicles and moving machinery maintenance. buy legal anabolic steroids online

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