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definition of equipoise

The drug is administered only intramuscularly (w / m) in institutions and in strict accordance with these instructions.
Treatment starts with a test administration (in case of ineffectiveness of further therapy is impractical) and evaluate the response (the dynamics of growth hormone secretion of growth, symptoms associated with carcinoid tumor).
The dosage regimen and duration of therapy is determined individually for each patient.
Begin to 30 mg / m 1 every 14 days. In inefficiency can increase the frequency of administration of 1 injection every 10 days.
Treatment of digestive organs fistula
treatment begins with a test to definition of equipoise evaluate intramuscular injection response. In the case of reducing the volume of discharge from the fistula by more than 50% within 72 hours after injection, the drug is used one time in ten days until healing of fistulas. The maximum number of additional injections – 3. In 50% of patients complete closure of fistulas has been observed for 14 days.

Instructions for the preparation and administration of the drug
mixing the freeze-dried with the supplied diluent should be performed immediately before injection by shaking the vial smooth movements, rotating the vial 20 or 30 times between the fingers until a homogeneous suspension of white or white with Valium a color shade. The suspension should not be mixed with other drugs.

 

Side effects: Local: itching, burning, mild transient pain at the injection site, sometimes accompanied by erythema. On the part of the digestive system organs: diarrhea or soft stools, steatorrhea, abdominal pain, flatulence, nausea, vomiting. With long-term use of the drug, the formation of gallstones (cholelithiasis asymptomatic). On the part of metabolism: rarely have seen an increase in glucose concentration, changes in glucose tolerance.

 

Overdose
Symptoms: The side effects definition of equipoise from the gastrointestinal tract, electrolyte disturbances. Treatment: symptomatic.

Interaction with other drugs
When concomitant administration of insulin amplifies its hypoglycemic effect, in this connection, the insulin dose should be adjusted. When concomitant administration with cyclosporine (orally), it is necessary to spend correction of doses of cyclosporine.

Cautions
In appointing Somatulina patients with diabetes (both type 1 and type 2) should be regular monitoring of blood glucose and, if necessary, carry out correction doses of hypoglycemic drugs.
When carcinoid tumors of the gastrointestinal treatment Somatulinom tract appointed after the removal of the existing intestinal obstruction by the tumor.
In the treatment of acromegaly is necessary to closely monitor the state of the pituitary gland.
prolonged treatment every 6 months is necessary to make an ultrasound examination of the gallbladder.
If abnormal liver or renal function is necessary to adjust the dose of the drug.
It is necessary to warn patients undergoing definition of equipoise treatment Somatulinom a possible violation of the reproductive function, as well as the appropriateness of the use of contraceptives during treatment Somatulinom and for 3 months after treatment.

Product form
30 mg lanreotide in a bottle of slightly darkened hydrolytic glass , rubber stoppers of chlorobutyl beneath an aluminum run with a hole for the needle in the center and covered with a protective plastic cover the control of the first opening.
In 2 ml of solvent in an ampoule colorless glass of hydrolytic .
One empty sterile disposable polypropylene syringe with a capacity of 3 ml and two sterile disposable needle tips (needle size 1,20 x 40 mm) in a blister pack made of PVC and laminated paper. One vial lanreotide, one vial with a solvent, a blister pack with two syringe needles and placed in a cardboard box, together definition of equipoise with instructions for use.

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