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equipoise cycle


Absorption – high, time of onset of the maximum concentration  in plasma – 1-4 hours after ingestion. About 90% of the drug binds to plasma proteins. It is metabolized in the liver with the formation of active metabolites (mesoridazine and sulforidazin).  Equipoise cycle – pharmacologically more active than the starting material, has a greater  less bound to proteins, free concentration higher than that of thioridazine. Excretion in unchanged form and as metabolites – the kidneys (35%) in the bile. Provided with breast milk.

Schizophrenia, manic-depressive psychosis; neuroses, accompanied by fear, anxiety, agitation, tension, depressed mood, sleep disturbances, intrusive state; psychotic disorders, accompanied by hyperactivity and excitement; severe behavioral disorders associated with psychotic disorders or neurological diseases involving aggression, inability to long-term focus; abstinence syndrome (drug addiction, alcoholism); agitation of various origins; moderate and severe depression in adults; Huntington’s disease, tics; skin conditions with a strong and painful itching; in child psychiatry is used for behavioral disorders with increased psychomotor activity.

Hypersensitivity, acute depression, comatose states from any cause, traumatic brain injuries, progressive system of the brain and spinal cord diseases; severe heart failure, severe hypotension, pheochromocytoma, porphyria, blood disorders (hypo-and aplastic processes). Pregnancy, lactation, children’s age (up to 4 years).

When alcoholism equipoise cycle (predisposition to hepatotoxicity), pathological changes in the blood (impaired hematopoiesis), breast cancer (as a result of induced phenothiazine prolactin increases the potential risk of disease progression and resistance to the treatment of endocrine and cytotoxic drugs), angle-closure glaucoma, prostatic hyperplasia with clinical manifestations, liver and / or renal failure, gastric ulcer and duodenal ulcer (in the period of exacerbation); diseases accompanied by an increased risk of thromboembolic complications; Parkinson’s disease (amplified extrapyramidal effects); epilepsy; myxedema;chronic diseases accompanied by respiratory disorders (especially in children); Reye syndrome (increased risk of hepatotoxicity in children and adolescents); cachexia, vomiting (antiemetic effect of phenothiazines may mask vomiting associated with overdoses of other drugs). Elderly age.

Dosing and Administration
Inside. An individual dosage regimen. Adult equipoise cycle Acute psychosis, mania, schizophrenia and depression azhitatsionnyh: an outpatient basis – 150-400 mg per day; hospital – 250-800 mg per day. Treatment is usually started with a low dosage of 25-75 mg per day, gradually increasing to an optimal therapeutic dose, which is usually achieved within 7 days, and the antipsychotic effect is observed after 10-14 days.The course of treatment is several weeks. Maintenance daily dose: 75-200 mg once daily at bedtime. In the treatment of the elderly are usually used low doses: 30-100 mg per day. The drug should be withdrawn gradually. In light of mental and emotional disorders – 30-75 mg per day, with moderate disorders – 50-200 mg per day. To begin treatment with low doses of gradually increasing doses until the optimal therapeutic. In psychosomatic disorders: 10-75 mg per day. To suppress the strong itch, dose set individually, and it should not exceed 200 mg. Children 4 to 7 years – 10-20 mg sutki.Kratnost reception – 2-3 times a day. From 8 to 14 years – 20 30 mg per day. Multiplicity of reception – 3 times a day. From 15 to 18 years – 30-50 mg per day. Multiplicity of reception – 3 times a day. buy anabolic steroids online bruce lee’s workout anabolic steroids online uk