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The metabolism of ibuprofen occurs predominantly in the liver. Excreted by the kidneys as metabolites (unchanged output is not more than 1%), to a lesser extent – in the bile.
Capsules sustained release “Solpafleks” yield increase the half-life of ibuprofen as compared with its conventional dosage forms provide extended duration of the drug to 12 hours.

Indications
capsule “Solpafleks” used to relieve joint, equipoise for sale muscle pain, back pain, back pain, sciatica, pain in damaged ligaments, headache, including migraine, dental pain, painful menstruation, feverish conditions, for colds, flu, rheumatoid arthritis, osteoarthritis.

Contraindications:
hypersensitivity, peptic ulcer and duodenal ulcer (in the acute stage), ulcerative colitis, optic nerve disease, amblyopia, impaired color vision, liver cirrhosis with portal hypertension, “Aspirin asthma” (provoked by taking aspirin or other. NSAIDs), heart insufficiency, edema, hypertension, hemophilia, anticoagulation, leukopenia, hemorrhagic diathesis, hearing loss, vestibular pathology, deficiency of glucose-6-phosphate dehydrogenase; pregnancy (III trimester), children up to 12 years.

Be wary – if hyperbilirubinemia, pregnancy, lactation; gastric ulcer and duodenal ulcer (in history), gastritis, enteritis, colitis; with liver and / or kidney failure, blood diseases of unknown etiology.

Dosage and administration Adults, elderly and children over 12 years: 1 – 2 capsules 2 times a day. Do not take more than 4 capsules in 24 hours. The capsules do not use in children under 12 years. The capsules should be swallowed with water. Do not chew or dissolve capsules! If you can not swallow the capsule, its contents can be poured into a tablespoon of soft cold food, such as yogurt and swallow without chewing. The course of treatment without consulting a doctor should not exceed 10 days. If you have forgotten in time to take medication, take it, as soon as remembered about it, provided that it took only a few hours. Otherwise, skip this intake and take the next dose at the usual time. If symptoms persist, consult a doctor.

Side effects of
drug is usually no side effects at the recommended doses. On the part of the gastrointestinal tract may include nausea, vomiting, abdominal pain, heartburn, anorexia, diarrhea, flatulence, equipoise for sale.Rarely in the nervous system are observed: headache, dizziness, hearing loss, tinnitus, insomnia, agitation, drowsiness, depression. In extremely rare cases, by the cardiovascular system: heart failure, tachycardia, increased blood pressure; on the part of the urinary system – edema, renal dysfunction. Allergic reaction – skin rash, itching, hives, angioedema. Sometimes it may increase sweating. With prolonged use at high doses -. Ulceration of the mucosa of the gastrointestinal tract, bleeding and blurred vision
if the drug caused a change in your normal state, stop taking the capsules “Solpafleks” and see a doctor immediately.

Overdose
Do not exceed the indicated dosage. If you exceed the dose, call your doctor or the nearest medical facility. Bring a package of the drug.
Overdose symptoms – abdominal pain, nausea, vomiting, lethargy, sleepiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest. First aid -promyvanie stomach (just an hour after ingestion), activated carbon, alkaline water.

Interactions
In therapeutic doses of ibuprofen does not enter into meaningful interactions with commonly used medications.
Inducers of enzymes of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, ziksorin, rifampin, phenylbutazone, tricyclic antidepressants) increase equipoise for sale the production of hydroxylated active metabolites, increasing the risk of severe intoksitkatsy. Inhibitors of microsomal oxidation – reduce the risk of hepatotoxicity.
Reduces hypotensive activity vasodilators natriuretic -furosemida and hydrochlorothiazide.
Reduces the uricosuric drugs, increases the effects of anticoagulants, antiplatelet agents, fibrinolytic agents (increased risk of bleeding), side effects mineralokortikosteroidov, glucocorticosteroids (risk of gastrointestinal intestinal bleeding), estrogens, ethanol; It enhances the hypoglycemic effect of sulfonylureas. Antacids and cholestyramine reduce the absorption. It increases the blood concentration of digoxin, drugs lithium and methotrexate.

Special instructions
for prolonged use is necessary to monitor patterns of peripheral blood and functional state of the liver and kidneys. When gastropathy symptoms should seek medical attention.
If necessary, the definition of 17-keto steroids equipoise for sale drug should be discontinued 48 hours prior to the study.
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