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equipoise side effects

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Absorption: Tamsulosin is absorbed in the small intestine, fasting bioavailability of almost 100%. When administered with food absorption of tamsulosin is reduced it. To achieve the same level of absorption of the drug should be taken daily in doses specified in the instructions, after breakfast. When receiving a long acting capsule 0.4 mg after meals maximum concentration  of the equipoise side effects drug in the plasma is achieved after about 6 hours. Repeated reception of the equilibrium concentration is reached by day 5, when maximum drug concentration in plasma of about 2-3 times higher than for single reception.Although these indicators were evaluated in elderly patients, assuming they have similar younger patients. When single and multiple reception can meet individual variations in plasma concentration of the drug.

 

Metabolism: Tamsulosin is metabolized slowly, the effect of “first pass” insignificant. Tamsulosin slowly biotransformed in the liver with the formation of pharmacologically active metabolites that retain high selectivity for alpha 1-adrenoceptor A. Most of the active substance is present in blood in an unmodified form. In rats revealed slight induction of microsomal caused by tamsulosin. None of the metabolites are not to be more active than tamsulosin.

Excretion: Tamsulosin and its metabolites are primarily excreted by the kidneys, approximately 9% of the dose of the drug – in an unmodified form. The half-life of the drug from plasma was 10 hours with a single reception capsules 0.4 mg, after repeated equipoise side effects hours, the final half-life -. 22 hours When kidney disease dose adjustment is required. Finasteride

Absorption: rapidly absorbed from the gastrointestinal tract after 2 hours reaches a maximum plasma concentration equal to 37 ng / ml. Absorption in the gastro-intestinal tract is completed in 6-8 hours after ingestion. Food intake has no effect on the absorption of finasteride. The bioavailability of finasteride when taken orally is approximately 80%.

Distribution: 90% of circulating finasteride is associated with plasma proteins and has no damaging effect in diseases of the kidneys. Finasteride penetrates the blood-brain barrier and seed is distributed to patients in a small amount of liquid. The volume of distribution was 76 ± 14 l.

Metabolism: Finasteride is extensively metabolised in the liver by oxidative biotransformation. Two of finasteride 5 metabolites have poor activity and are responsible for 20% of inhibition .

Excretion: The average half-life of finasteride is 6 hours equipoise side effects, in men older than 70 years – 8 hours (6-15 hours). When using labeled finasteride, approximately  of the administered dose excreted by the kidneys as metabolites. Unchanged finasteride virtually undetectable in urine. Approximately  of the total dose is excreted through the intestines. Patients with narusheniehM renal function revealed no differences in excretion of finasteride. Finasteride in sperm concentration ranges from undetectable .
Long, 3-7 months receiving 5 mg / day, reduces the concentration of equipoise side effects in the serum by 70%.

Pharmacokinetics in specific patient groups:
In elderly patients Finasteride displays a little slower, but it has no clinical significance and does not require dose adjustment. This also applies to patients with renal insufficiency, as a decrease in renal excretion of metabolites offset by increased excretion of the drug through the intestines. Indicators pharmacokinetics of finasteride has not been studied in patients equipoise side effects with hepatic insufficiency. Since Finasteride is extensively metabolised in the liver, liver diseases require additional monitoring.

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